Browsing by Author "Atik, Sinem"
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Association between ABCB1 (MDR1) Gene 3435 C > T Polymorphism and Colchicine Unresponsiveness of FMF Patients
Ozen, Filiz; Silan, Coskun; Uludag, Ahmet; Candan, Ferhan; Silan, Fatma; Ozdemir, Semra; Atik, Sinem; Ozdemir, Ozturk (TAYLOR & FRANCIS LTD, 2011)The multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in protecting cells from xenobiotics, chemicals, and ... -
Combined Effect of Factor V Leiden, MTHFR, and Angiotensin-Converting Enzyme (Insertion/Deletion) Gene Mutations in Hypertensive Adult Individuals: A Population-Based Study from Sivas and Canakkale, Turkey
Demirel, Yeltekin; Dogan, Sezai; Uludag, Ahmet; Silan, Coskun; Atik, Sinem; Silan, Fatma; Ozdemir, Ozturk (MARY ANN LIEBERT INC, 2011)Background: Hypertension is one of the leading causes of mortality and morbidity in the world, which is influenced by environmental and genetic factors. The methylenetetrahydrofolate reductase (MTHFR) and angiotensin-converting ... -
Combined point mutations in codon 12 and 13 of KRAS oncogene in prostate carcinomas
Silan, Fatma; Gultekin, Yener; Atik, Sinem; Kilinc, Davran; Alan, Cabir; Yildiz, Fazilet; Uludag, Ahmet; Ozdemir, Ozturk (SPRINGER, 2012)Prostate cancer is a common malignancy that develops by structural mutation(s) and/or other genetic alterations in specific genes.The G to T transversions in codon 12 and C to T transitions in codon 13 of KRAS proto-oncogene ... -
Increased T-Allele Frequency of 677 C > T Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Differentiated Thyroid Carcinoma
Ozdemir, Semra; Silan, Fatma; Hasbek, Zekiye; Uludag, Ahmet; Atik, Sinem; Erselcan, Taner; Ozdemir, Ozturk (MARY ANN LIEBERT INC, 2012)Background: Epigenetic alterations in the global DNA methylation status may be associated with an increased risk of some cancer types in humans. The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic ... -
The prevalence of VKORC1 1639 G > A and CYP2C9*2*3 genotypes in patients that requiring anticoagulant therapy in Turkish population
Silan, Coskun; Dogan, Omer Tamer; Silan, Fatma; Kukulguven, Fatma Mutlu; Asgun, Halil Fatih; Ozdemir, Semra; Uludag, Ahmet; Atik, Sinem; Gungor, Buket; Akdur, Secil; Aksulu, Hakki Engin; Ozdemir, Ozturk (SPRINGER, 2012)The aim was to investigate the prevalence of VKORC1 and CYP2C9 genotypes in patients requiring anticoagulant therapy in two different region's populations of Turkey. The recent cohort included 292 patients that needed ... -
Recurrent Pregnancy Loss and Its Relation to Combined Parental Thrombophilic Gene Mutations
Ozdemir, Ozturk; Yenicesu, Gonca Imir; Silan, Fatma; Koksal, Binnur; Atik, Sinem; Ozen, Filiz; Gol, Mert; Cetin, Ali (MARY ANN LIEBERT, INC, 2012)Background and Aim: Recurrent pregnancy loss (RPL) is a heterogeneous disorder that has been associated with antiphospholipid syndrome and other prothrombotic parameters. We aimed to investigate the prevalence of 12 ...